While the broader crypto market faces renewed pressure, meme coins are showing surprising strength—posting solid 7-day gains and outperforming much of the digital asset space.
This resilience comes amid growing optimism that the pro-crypto U.S. administration will soon unveil a comprehensive regulatory framework. In his first week back in office, President Trump signed an Executive Order establishing both a U.S. Strategic Bitcoin Reserve and a roadmap for crypto regulation.
Momentum is building. South Carolina has already passed a bill calling for its own state Bitcoin reserve, signaling that the tide may finally be turning in favor of mainstream crypto adoption.
With conditions slowly aligning for the next major bull run, now may be the perfect time to secure positions in projects with breakout potential.
Below are three of the most promising meme coins on the market—top picks to watch closely ahead of what could be a major weekend move.
Dogecoin ($DOGE) – The Founding Meme Coin Continues to Lead the Pack
The pioneering meme-based cryptocurrency, Dogecoin ($DOGE), remains the sector’s most influential asset, boasting a substantial market capitalization of $27 billion—around half of the total meme coin market’s $54.8 billion valuation.
Dogecoin started life in 2013. It began as a satirical project aimed at poking fun at the craze of minting new cryptocurrencies. Its creators Billy Markus and Jackson Palmer decided to use the ever popular Doge meme for their avatar and thus the original and best meme coin was born.
Throughout 2025, Dogecoin’s resistance and support levels have declined considerably, moving from $0.40 to $0.20 and from $0.32 to $0.15, respectively.
This is in line with Bitcoin’s price movements over the period and is a reflection of the people’s risk-off outlook, due to current geopolitical tensions and macroeconomic uncertainties across the globe.
There are growing signs that a weekend pump may be brewing. Dogecoin has been on a steady upward trend since March 11, mirroring the price action of $PEPE. Over the past seven days, DOGE has gained 7.6%—and more upside could be on the horizon.
With a relative strength index (RSI) of 28, Dogecoin is now in oversold territory, often a signal that buyers are preparing to jump in and capitalize on the discount.
Dogecoin’s enduring appeal stems from high-profile endorsements by figures like Elon Musk, Gene Simmons, and Snoop Dogg, as well as real-world utility—such as being accepted for purchases at Tesla’s online store.
As one of the most accessible meme coins on the market—tradable on top exchanges and supported by platforms like Revolut and PayPal—DOGE is well-positioned for a strong rebound as sentiment turns bullish.
Meme Index ($MEMEX): A Strategic Approach to Investing in Meme Coins
Meme Index ($MEMEX) offers a diversified and structured approach to meme coin investing through a community-driven index fund model.
Rather than speculating on individual meme coins, investors can distribute their capital across multiple meme coin indexes, categorized by varying risk levels.
Additionally, $MEMEX token holders can actively participate in governance decisions that influence which cryptocurrencies go into or leave the baskets.
So far, Meme Index has raised $4.3 million in presale investments, with many early investors piling into its staking platform, which currently offers a very generous yield of 539% APY, although this number will decline as more participants join the pool.
With the meme coin market surpassing a collective valuation of $50 billion, Meme Index presents a structured and diversified gateway into this rapidly expanding sector, optimizing investment opportunities in this notoriously volatile subsector.
Pepe ($PEPE) – The Boy’s Club Classic Meme Coin Maintains Its Reign
Pepe ($PEPE) is the blockchain iteration of Pepe the Frog, a character originating from Max Furie’s Boy’s Club comic series, achieved worldwide recognition as a meme before he became a cryptocurrency. Originally an internet cultural icon known for the phrase “feels good, man” he was even spotted as a protest symbol during the 2019 Hong Kong demonstrations.
In April 2023, Pepe entered the cryptocurrency landscape under the ticker $PEPE, inspiring a new wave of Pepe-inspired meme coin projects, including Pepe Coin and the new AI-integrated MIND of Pepe.
None has competed with the original and the best, though. Pepe has since grown to achieve a market capitalization exceeding $3.3 billion.
Over the past 24 hours, $PEPE has dipped by 8%, but it still holds a 7.4% gain over the past week—tracking closely with Dogecoin’s recent price action.
After enduring a three-month downtrend, the meme coin appears to be regaining momentum, rebounding off its March 11 low of $0.00000561.
The token is now approaching a key support level at $0.000001, and with its Relative Strength Index (RSI) down to 27, PEPE has entered oversold territory—often a signal that a reversal could be imminent.
As market participants await further regulatory clarity from the new U.S. administration, momentum is building behind top meme coins like PEPE.
With sentiment shifting and investor interest returning, this weekend could mark the beginning of a broader meme coin resurgence.
The post Best Meme Coins to Buy Now – Weekend Pump Incoming? appeared first on Cryptonews.
